Although psychotic disorders are relatively common, we have to this date not been able to reliably predict the course and outcome of psychosis at an individual level.
The study aims to recruit a sample of 500 patients with a first episode of psychosis, aged 16-40 years as well as a smaller sample of healthy controls. The study aims at predicting illness course and outcome in patients with a first episode of psychosis on the basis of measures of psychopathology, brain structure and function, cognition, and biological markers in blood. These data will be used to develop and validate a quantitative and objective tool that will enable healthcare professionals to tailor psychiatric care to the particular needs of each patient.
The study has been initiated by researchers at the Department of Psychiatry at University Medical Center Utrecht and is performed in collaboration with partners across Europe as well as in Israel and Australia. Inclusion began in 2017 and is expected to conclude in 2019.