Source localization of sensory gating: in search of endophenotypes in schizophrenia

​This multimodal study combined electroencephalography (EEG) with functional magnetic resonance imaging (fMRI). The aim was to identify the brain sources responsible for sensory gating measured with a P50 suppression paradigm and further to identify the structures responsible for the deficient gating in schizophrenia.

Schizophrenia is frequently accompanied by deficits in basic information processing, such as sensory gating. This study explored the brain structures involved in sensory gating measured with a somatosensory P50 suppression paradigm. The study measured both electroencephalography (EEG) concurrent with functional magnetic resonance imaging (fMRI). 23 patients and 20 healthy controls were included between 2008 and 2010.

 

The combination of fMRI and EEG source localization can give more detailed information regarding the sources of sensory gating, since the EEG methodology has a high temporal resolution, whereas the fMRI has a high spatial resolution. With this combination it is also possible to ensure whether P50 suppression was actually present during the fMRI scanning rather than assuming it is the same as in a separate EEG setting.

 

PhD theses based on data from this project:

  • Nikolaj Bak "Source localization of sensory gating: Concurrent EEG and fMRI assessment of P50 suppression" (2011)

 

Selected articles based on data from this project:

  • Source localization of sensory gating: a combined EEG and fMRI study in healthy volunteers
  • Bak, N., Glenthøj, B. Y., Rostrup, E., Larsson, H. B. & Oranje, B. Source localization of sensory gating: a combined EEG and fMRI study in healthy volunteers. 2011. NeuroImage. 54, 4, pp. 2711-8.
  • Bak, N., Rostrup, E., Larsson, H. B. W., Glenthøj, B. Y. & Oranje, B. Concurrent functional magnetic resonance imaging and electroencephalography assessment of sensory gating in schizophrenia. 2014. Human brain mapping. 35, 8, pp. 3578–3587.
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