Publications

Ott et al. Norms for the Screen for Cognitive Impairment in Psychiatry and cognitive trajectories in bipolar disorder. J Affect Disord. 2020 (in press).

Hørlyck LD, Obenhausen K, Jansari A, Ullum H, Miskowiak KW. Virtual reality assessment of daily life executive functions in mood disorders: associations with neuropsychological and functional measures. J Affect Disord. 2020

Ott CV, Macoveanu J, Bowie CR, Fisher PM, Knudsen GM, Kessing LV, Miskowiak KW. Change in prefrontal activity and executive functions after action-based cognitive remediation in bipolar disorder: a randomized controlled trial. Neuropsychopharmacology. 2020 

Bjertrup AJ, Jensen MB, Schjødt MS, Parsons CE, Kjærbye-Thygesen A, Mikkelsen RL, Moszkowicz M, Frøkjær VG, Vinberg M, Kessing LV, Væver MS, Miskowiak KW. Cognitive processing of infant stimuli in pregnant women with and without affective disorders and the association to postpartum depression. Eur Neuropsychopharmacol. 2020 

Faurholt-Jepsen M, Miskowiak KW, Frost M, Christensen EM, Þórarinsdóttir H, Bardram JE, Vinberg M, Kessing LV. Patient-evaluated cognitive function measured with smartphones and the association with objective cognitive function, perceived stress, quality of life and function capacity in patients with bipolar disorder. Int J Bipolar Disord. 2020

Miskowiak KW. Erythropoietin as possible treatment of brain diseases. Ugeskr Laeger. 2020

Ott CV, Vinberg M, Kessing LV, Bowie CR, Forman JL, Miskowiak KW. Effect of Action-Based Cognitive Remediation on cognitive impairment in patients with remitted bipolar disorder: A randomized controlled trial. Bipolar Disord. 2020 

Seeberg I, Nielsen IB, Jørgensen CK, Eskestad ND, Miskowiak KW. Effects of psychological and pharmacological interventions on anxiety symptoms in patients with bipolar disorder in full or partial remission: A systematic review. J Affect Disord. 2020

Knorr U, Miskowiak K, Akhøj M, Vinberg M, Forman J, Kessing LV. The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study. J Affect Disord.

Ottesen NM, Meluken I, Frikke-Schmidt R, Plomgaard P, Scheike T, Kessing LV, Miskowiak K, Vinberg M. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders. J Affect Disord. 2020 

Macoveanu J, Meluken I, Kessing LV, Siebner HR, Vinberg M, Miskowiak KW. Hippocampal subfield morphology in monozygotic twins discordant for affective disorders. Neuropsychopharmacology. 2020 

Varo C, Solé B, Jiménez E, Bonnín CM, Torrent C, Valls E, Lahera G, Martínez-Arán A, Carvalho AF, Miskowiak KW, Vieta E, Reinares M. Identifying social cognition subgroups in euthymic patients with bipolar disorder: a cluster analytical approach. Psychol Med. 2020

Ehrenreich H, Weissenborn K, Begemann M, Busch M, Vieta E, Miskowiak KW. Erythropoietin as candidate for supportive treatment of severe COVID-19. Mol Med. 2020

Ehrenreich H, Neubauer AP, Miskowiak K. Erythropoietin in Preterm Infants. N Engl J Med. 2020

Macoveanu J, Kjaerstad HL, Chase HW, Frangou S, Knudsen GM, Vinberg M, Kessing LV, Miskowiak KW. Abnormal prefrontal cortex processing of reward prediction errors in recently diagnosed patients with bipolar disorder and their unaffected relatives. Bipolar Disord. 2020

Wakhloo D, Scharkowski F, Curto Y, Javed Butt U, Bansal V, Steixner-Kumar AA, Wüstefeld L, Rajput A, Arinrad S, Zillmann MR, Seelbach A, Hassouna I, Schneider K, Qadir Ibrahim A, Werner HB, Martens H, Miskowiak K, Wojcik SM, Bonn S, Nacher J, Nave KA, Ehrenreich H. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nat Commun. 2020

Petersen CS, Miskowiak KW. Toward a transdiagnostic neurocircuitry-based biomarker model for pro-cognitive effects: challenges, opportunities, and next steps. CNS Spectr. 2020

Macoveanu J, Meluken I, Chase HW, Phillips ML, Kessing LV, Siebner HR, Vinberg M, Miskowiak KW. Reduced frontostriatal response to expected value and reward prediction error in remitted monozygotic twins with mood disorders and their unaffected high-risk co-twins. Psychol Med. 2020

Kjærstad HL, Jørgensen CK, Broch-Due I, Kessing LV, Miskowiak K. Eye gaze and facial displays of emotion during emotional film clips in remitted patients with bipolar disorder. Eur Psychiatry. 2020

Miskowiak KW, Lewandowski KE. Trajectory of cognitive functions in bipolar disorder: for better or worse? Acta Psychiatr Scand. 2020 Feb;141(2):95-97. 

Jensen NJ, Nilsson M, Ingerslev JS, Olsen DA, Fenger M, Svart M, Møller N, Zander M, Miskowiak KW, Rungby J. Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes. Eur J Endocrinol. 2020 Feb;182(2):233-242.

Miskowiak KW, Forman JL, Vinberg M, Siebner HR, Kessing LV, Macoveanu J. Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial. J Psychiatry Neurosci. 2020 May 1;45(3):198-205

Miskowiak KW, Seeberg I, Kjaerstad HL, Burdick KE, Martinez-Aran A, Del Mar Bonnin C, Bowie CR, Carvalho AF, Gallagher P, Hasler G, Lafer B, López-Jaramillo C, Sumiyoshi T, McIntyre RS, Schaffer A, Porter RJ, Purdon S, Torres IJ, Yatham LN, Young AH, Kessing LV, Van Rheenen TE, Vieta E. Affective cognition in bipolar disorder: A systematic review by the ISBD targeting cognition task force. Bipolar Disord. 2020;21(8):686-719. 

Ottesen NM, Meluken I, Frikke-Schmidt R, Plomgaard P, Scheike T, Fernandes BS, Berk M, Poulsen HE, Kessing LV, Miskowiak K, Vinberg M. Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? - a monozygotic twin study. Psychol Med. 2020 Jul;50(10):1736-1745.

Kjærstad HL, Mistarz N, Coello K, Stanislaus S, Melbye SA, Harmer CJ, Vinberg M, Miskowiak K, Kessing LV. Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives. Psychol Med. 2020 Aug;50(11):1808-1819.

Van Rheenen TE, Lewandowski KE, Bauer IE, Kapczinski F, Miskowiak K, Burdick KE, Balanzá-Martínez V. Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence. Bipolar Disord. 2020 Feb;22(1):13-27.

Vestergaard M, Kongerslev MT, Thomsen MS, Mathiesen BB, Harmer CJ, Simonsen E, Miskowiak KW. Women With Borderline Personality Disorder Show Reduced Identification of Emotional Facial Expressions and a Heightened Negativity Bias. J Pers Disord. 2020 Oct;34(5):677-698.

Meluken, I., Ottesen, N., Harmer, C., Macoveanu, J., Siebner, H., Kessing, L., ... & Miskowiak, K. (2019). Neural response to emotional faces in monozygotic twins: association with familial risk of affective disorders. Journal of psychiatry & neuroscience: JPN, 44(3), 1-10.

Ott, C. V., Johnson, C. B., Macoveanu, J., & Miskowiak, K. (2019). Structural changes in the hippocampus as a biomarker for cognitive improvements in neuropsychiatric disorders: A systematic review. European Neuropsychopharmacology.

Petersen, J. Z., Porter, R. J., & Miskowiak, K. W. (2019). Clinical characteristics associated with the discrepancy between subjective and objective cognitive impairment in depression. Journal of affective disorders, 246, 763-774.

Meluken, I., Ottesen, N. M., Phan, K. L., Goldin, P. R., Di Simplicio, M., Macoveanu, J., ... & Miskowiak, K. W. (2019). Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders. NeuroImage: Clinical, 21, 101598.

Ottesen, N. M., Meluken, I., Scheike, T., Kessing, L. V., Miskowiak, K. W., & Vinberg, M. (2018). Clinical characteristics, life adversities and personality traits in monozygotic twins with, at risk of and without affective disorders. Frontiers in psychiatry, 9.

Petersen, J. Z., Schmidt, L. S., Vinberg, M., Jørgensen, M. B., Hageman, I., Ehrenreich, H., Knudsen, G.M., Kessing, L.V., & Miskowiak, K. W. (2018). Effects of recombinant human erythropoietin on cognition and neural activity in remitted patients with mood disorders and first-degree relatives of patients with psychiatric disorders: a study protocol for a randomized controlled trial. Trials, 19(1), 611.

Kessing, L. V., & Miskowiak, K. (2018). Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper. Frontiers in Psychiatry, 9.

Ottesen, N. M., Meluken, I., Scheike, T., Kessing, L. V., Miskowiak, K. W., & Vinberg, M. (2018). Clinical Characteristics, Life Adversities and Personality Traits in Monozygotic Twins With, at Risk of and Without Affective Disorders. Frontiers in psychiatry, 9.

Ott, C. V., Vinberg, M., Bowie, C. R., Christensen, E. M., Knudsen, G. M., Kessing, L. V., & Miskowiak, K. W. (2018). Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials, 19(1), 487.

Miskowiak, K. W., & Petersen, C. S. (2018). Neuronal underpinnings of cognitive impairment and-improvement in mood disorders. CNS spectrums, 1-24.

Seeberg, I., Kjærstad, H. L., & Miskowiak, K. (2018). Neural and behavioral predictors of treatment efficacy on mood symptoms and cognition in mood disorders: A systematic review. Frontiers in psychiatry, 9, 337.

Macoveanu, J., Demant, K. M., Vinberg, M., Siebner, H. R., Kessing, L. V., & Miskowiak, K. W. (2018). Towards a biomarker model for cognitive improvement: No change in memory-related prefrontal engagement following a negative cognitive remediation trial in bipolar disorder. Journal of Psychopharmacology, 32(10), 1075-1085.

Meluken, I., Ottesen, N. M., Harmer, C. J., Scheike, T., Kessing, L. V., Vinberg, M., & Miskowiak, K. W. (2018). Is aberrant affective cognition an endophenotype for affective disorders?–A monozygotic twin study. Psychological medicine, 1-10.

Miskowiak, K. W., Macoveanu, J., Jørgensen, M. B., Ott, C. V., Støttrup, M. M., Jensen, H. M., ... & Kessing, L. V. (2018). Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study. European Neuropsychopharmacology.

Miskowiak, K. W., Petersen, N. A., Harmer, C. J., Ehrenreich, E., Kessing, L. V., Vinberg, M., ... & Siebner, H. R. (2018). Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder. Acta Psychiatrica Scandinavica, 138(4), 336-347.

Broch-Due, I., Kjærstad, H. L., Kessing, L. V., & Miskowiak, K. (2018). Subtle behavioural responses during negative emotion reactivity and down-regulation in bipolar disorder: A facial expression and eye-tracking study. Psychiatry research, 266, 152-159.

Petersen, J. Z., & Miskowiak, K. W. (2018). Cognitive side effects of electroconvulsive therapy. Ugeskrift for laeger, 180(18).

Miskowiak, K. W., Macoveanu, J., Jørgensen, M. B., Støttrup, M. M., Ott, C. V., Jensen, H. M., ... & Siebner, H. R. (2017). Neural response after a single ECT session during retrieval of emotional self-referent words in depression: a randomized, sham-controlled fMRI study. International Journal of Neuropsychopharmacology, 21(3), 226-235.

Schmidt, L. S., Petersen, J. Z., Vinberg, M., Hageman, I., Olsen, N. V., Kessing, L. V., ... & Miskowiak, K. W. (2018). Erythropoietin as an add-on treatment for cognitive side effects of electroconvulsive therapy: a study protocol for a randomized controlled trial. Trials, 19(1), 234.

Kærsgaard, S., Meluken, I., Kessing, L. V., Vinberg, M., & Miskowiak, K. W. (2018). Increased sensitivity to positive social stimuli in monozygotic twins at risk of bipolar vs. unipolar disorder. Journal of affective disorders, 232, 212-218.

Miskowiak, K. W., Burdick, K. E., Martinez‐Aran, A., Bonnin, C. M., Bowie, C. R., Carvalho, A. F., ... & McIntyre, R. S. (2018). Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians. Bipolar disorders, 20(3), 184-194

Miskowiak KW, Burdick KE, Martinez-Aran A, Bonnin CM, Bowie CR, Carvalho AF, Gallagher P, Lafer B, López-Jaramillo C, Sumiyoshi T, McIntyre RS, Schaffer A, Porter RJ, Torres IJ, Yatham LN, Young AH, Kessing LV, Vieta E. (2017). Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force.

Kjær KS, Hageman I, Wörtwein G, Jørgensen MB, Miskowiak KW. (2017). Erythropoietin treatment may improve cognition in neuropsychiatricdisorders.

Miskowiak KW, Larsen JE, Harmer CJ, Siebner HR, Kessing LV, Macoveanu J, Vinberg M. (2017). Is negative self-referent bias an endophenotype for depression? An fMRI study of emotional self-referent words in twins at high vs. low risk of depression.

Miskowiak KW, Kjaerstad HL, Støttrup MM, Svendsen AM, Demant KM, Hoeffding LK, Werge TM, Burdick KE, Domschke K, Carvalho AF, Vieta E, Vinberg M, Kessing LV, Siebner HR, Macoveanu J. (2017). The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder.

Miskowiak KW, Svendsen AM, Harmer CJ, Elliott R, Macoveanu J, Siebner HR, Kessing LV, Vinberg M. (2017). Differences in neural and cognitive response to emotional faces in middle-aged dizygotic twins at familial risk of depression. Psychol Med.

Miskowiak KW, Kjaerstad HL, Støttrup MM, Svendsen AM, Demant KM, Hoeffding LK, Werge TM, Burdick KE, Domschke K, Carvalho AF, Vieta E, Vinberg M, Kessing LV, Siebner HR, Macoveanu J. (2017). The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder. Bipolar Disord.

Elias, L. R., Miskowiak, K. W., Vale, A. M., Köhler, C. A., Kjærstad, H. L., Stubbs, B., ... & Carvalho, A. F. (2017). Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis. Journal of the American Academy of Child & Adolescent Psychiatry.

Miskowiak, K. W., Kessing, L. V., Ott, C. V., Macoveanu, J., Harmer, C. J., Jørgensen, A., ... & Jørgensen, M. B. (2017). Does a single session of electroconvulsive therapy alter the neural response to emotional faces in depression? A randomised sham-controlled functional magnetic resonance imaging study. Journal of Psychopharmacology.

Miskowiak KW (2016). Could EPO studies improve mood disorder treatment strategies? Expert Rev Neurother.

Miskowiak KW, Kjærstad HL, Meluken I, Petersen JZ, Maciel BR, Köhler CA, Vinberg M, Kessing LV, Carvalho AF (2016). The search for neuroimaging and cognitive endophenotypes: A criticial systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder. Neurosci Biobehav Rev.

Miskowiak KW, Ott CV, Petersen JZ, Kessing LV (2016). Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field. Eur Neuropsychopharmacol.

Miskowiak KW, Petersen JZ, Ott CV, Knorr U, Kessing LV, Gallagher P, Robinson L (2016). Predictors of the discrepancy between objective and subjective cognition in bipolar disorder: a novel methodology. Acta Psychiatr Scand.

Miskowiak KW, Carvalho AF, Vieta E, Kessing LV.​​ (2016). Cognitive enhancement treatments for bipolar disorder: A systematic review and methodological recommendations. Eur Neuropsychopharmacol.​

Jensen JH, Knorr U, Vinberg M, Kessing LV, Miskowiak KW​. (2016). Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder: Associations with functional abilities. J Affect Disord.​​

Ott, C.V., Vinberg, M., Kessing, L.V., & Miskowiak, K.W. (2016). The effect of erythropoietin on cognition in affective disorders - Associations with baseline deficits and change in subjective cognitive complaints​. European Neuropsychopharmacology.

Miskowiak, K.W., Macoveanu, J., Vinberg, M., Assentoft, E., Randers, L., Harmer, C.J., ... & Kessing, L.V. (2016). Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders​. Acta Psychiatrica Scandinavica.​

Vinberg M, Weikop P, Olsen NV, Kessing LV, Miskowiak K. (2016): Effect of recombinant erythropoietin on inflammatory markers in patients with affective disorders: A randomised controlled study​, Brain, behavior, and immunity.

Miskowiak, K. W., Rush, J. A., Gerds, T. A., Vinberg, M., & Kessing, L. V. (2016). Targeting Treatments to Improve Cognitive Function in Mood Disorder: Suggestions From Trials Using Erythropoietin. The Journal of clinical psychiatry, 77(12), e1639-e1646.

Miskowiak KW, Vinberg M, Glerup L, Paulson OB, Knudsen GM, Ehrenreich H, Harmer CJ, Kessing LV, Siebner HR, Macoveanu J (2016): Neural correlates of improved executive function following erythropoietin treatment in mood disorders, Psychological Medicine, 46(8), 1679-1691.

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2015): Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. Biological Psychiatry 78(4):270-7

Kjaerstad KH, Vinberg M, Goldin PR, Koester N, Stoettrup MM, Knorr U, Kessing LV, Miskowiak KW (2016): Impaired down-regulation of negative emotion in self-referent social situations in bipolar disorder: A pilot study of a novel experimental paradigm, Psychiatry Research (in press)

Ott CV, Bjertrup AJ, Jensen JH, Ullum H, Sjælland R, Purdon SE, Vieta E, Kessing LV, Miskowiak KW (2016): Screening for cognitive dysfunction in unipolar depression: validation and evaluation of objective and subjective tools, Journal of Affective Disorders 190:607-15

Jensen JH, Støttrup MM, Nayberg E, Knorr U, Ullum H, Purdon SE, Miskowiak KW (2015): Optimising screening for cognitive dysfunction in bipolar disorder: validation and evaluation of objective and subjective tools, Journal of Affective Disorders 187:10-19

Demant KM, Vinberg M, Kessing KV, Miskowiak KW (2015): Assessment of subjective and objective cognitive function in bipolar disorder: correlations, predictors and the relation to psychosocial function. Psychiatry Research 229(1-2):565-71

Demant KM, Vinberg M, Kessing KV, Miskowiak KW (2015): Effects of short-term cognitive remediation on cognitive dysfunction in partially or fully remitted individuals with bipolar disorder: results of a randomised controlled trial. PLoS One 10(6):e01279

Miskowiak KW, Glerup L, Vestbo C, Harmer CJ, Reinecke A, Macoveanu J, Siebner HR, Kessing LV, Vinberg M (2015): Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. Psychological Medicine 45(7):1447-58

Vinberg M, Miskowiak KW, Jensen PH, Pedersen M, Kessing LV (2015):The effect of recombinant erythropoietin on plasma brain derived neurotrophic factor levels in patients with affective disorders: a randomised controlled study. PLoS One 10(5):e0127629

Miskowiak KW, Ehrenreich H, Kessing LV, Vinberg M (2015): Dr Miskowiak and colleagues reply. Journal of Clinical Psychiatry 76(6):e835-6

Østergaard SD, Bech P, Miskowiak KW (2014): Fewer study participants needed to demonstrate superior antidepressant efficacy ​when using the Hamilton melancholia subscale (HAM-D6) as outcome measure. J Affect Disord (in press)

Miskowiak KW, Carvalho A (2014): 'Hot' cognition in depression: a systematic review. CNS & Neurological Disorders – Drug Targets 13(10):1787-803 [Impact Factor: 2.7]

Miskowiak KW, Ehrenreich H, Christensen EM, Kessing LV, Vinberg M (2014): Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: A double-blind, randomized, placebo-controlled phase 2 trial. Journal of Clinical Psychiatry 75(12):1347-55

Miskowiak KW, Vinberg M, Christensen EM, Bukh JD, Harmer CJ, Ehrenreich H, Kessing LV (2014): Recombinant human erythropoietin for treating treatment-resistant depression: A double-blind, randomized, placebo-controlled phase 2 trial. Neuropsychopharmacology 39(6):1399-1408

Demant KM, Almer GM, Vinberg M, Kessing LV, Miskowiak KW (2013):Effects of cognitive remediation on cognitive dysfunction in partially or fully remitted patients with bipolar disorder: study protocol for a randomized controlled trial. Trials14(1):378

Svendsen AM, Miskowiak K, Vinberg M (2013): Risk of long-lasting negative cognitive consequences after electroconvulsive therapy. Danish Medical Journal 175(44):2649-2650

Vinberg M, Miskowiak KW, Kessing LV (2013): Impairment of executive function and attention predicts onset of affective disorder in healthy high-risk twins. Journal of Clinical Psychiatry 74(8):747-53

Vinberg M, Miskowiak K, Kessing LV (2013): Risk markers for affective disorder, a seven-years follow up study of a twin cohort at low and high risk for affective disorder. Journal of Psychiatric Research 47: 565–71

Miskowiak KW, Vinberg M, Harmer CJ, Ehrenreich H, Kessing LV (2012): Erythropoietin – a candidate treatment for mood symptoms and memory dysfunction in depression. Psychopharmacology (Berlin) 219(3):687-98 [Impact Factor: 3.9]

Svendsen AM, Vinberg M, Munkholm K, Kessing LV, Miskowiak KW (2012): Is there an association between subjective and objective measures of cognitive function in patients with affective disorders?Nordic Journal of Psychiatry 66:248-53

Miskowiak KW, Vinberg M, Christensen EM, Kessing KV (2012): Is there a difference in subjective experience of cognitive function in patients with unipolar disorder versus bipolar disorder? Nordic Journal of Psychiatry ​66(6):389-39

Miskowiak KW, Vinberg M, Harmer CJ, Ehrenreich H, Knudsen GM, Macoveanu J, et al. (2010): Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials 11: 97​

Miskowiak KW & Kessing LV (2016): Cognitive enhancement in bipolar disorder: current evidence and methodological considerations, chapter 23 in 'The Treatment of Bipolar Disorder: Integrative treatment strategies and Future Directions', edited by Carvalho C & Vieta E, Oxford University Press.

Miskowiak KW (2015): A novel treatment for cognitive dysfunction in mood disorders, chapter 21 in 'Cognitive Dysfunction in Major Depressive Disorder', edited by McIntyre R & Cha D, Cambridge University Press.​​​​​