Publications

CINS's research results have been published in various national and international high-impact journals.

A full list of publications is available here.


Cohorts


Cohart A

1. Fagerlund B, Mackeprang T, Gade A, Hemmingsen R, and Glenthøj B. The effects of antipsychotics on executive functions in drug-naïve first-episode schizophrenics. Brief report udvalgt efter eksternt review, 10th annual Rotman Research Institute Conference: The frontal lobes. (Toronto March 2000). Brain & Cognition.2001; 47 (1-2):249-52. 

2. Mackeprang T, Tjelle Kristiansen K, Glenthøj B. Effects of antipsychotics on prepulse inhibition of the startle response in drug-naïve schizophrenic patient. Biol Psychiatr 2002;52(9):863-73. 

3. Fagerlund B, Mackeprang T, Gade A, Hemmingsen R, Glenthøj BY. Effects of Low-Dose Risperidone and Low-Dose Zuclopenthixol on Cognitive Functions in First-Episode Drug-Naïve Schizophrenic Patients. CNS Spectr. 2004;9:364-74. 

4. Glenthoj BY, Mackeprang T, Svarer C, Rasmussen H, Pinborg L, Friberg L, Baaré W, Hemmingsen R, Videbæk C. Frontal dopamine D2/3 receptor binding in drug-naïve first-episode schizophrenic patients correlates with positive psychotic symptoms and gender. Biol Psychiatr 2006;60(6):621-9. 

5. Pinborg LH, Videbæk C, Zibell M, Mackeprang T, Friberg L, Knudsen GM, Glenthoj BY. [ 123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region. Neuroimage 2007;34:1450-3. 

6. Glenthoj A, Glenthoj B, Mackeprang T, Pagsberg AK, Hemmingsen RP, Jernigan TL, Baaré WFC. Altered asymmetry of caudate nucleus in drug-naïve first-episode schizophrenic patients. Psychiatr Res 2007; 154(3):199-208. 

7. Hammer TB, Oranje B, Fagerlund B, Bro H, Glenthøj BY. Stability of Prepulse Inhibition and habituation of the Startle Reflex in Schizophrenia: A 6 Year Follow-up Study of Initially Antipsychotic Naïve, First-Episode Schizophrenia patients. Int J Neuropsychopharm 2011;14(7):913-25. 

8. Fagerlund B, Pinborg LH, Mortensen EL, Friberg LL, Baaré WF, Gade A, Svarer C, Glenthøj BY. Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naïve schizophrenia patients. Int J Neuropsychopharmacol 2013 Feb;16(1):23-36. 

9. Hammer TB, Oranje B, Skimminge A, Ebdrup B, Aggernaes B, Glenthøj B, Baaré W. Structurel brain correlates of sensorimotor gating in antipsychotic naïve, first episode Schizophrenia patients. J Psychiatr Neurosci 2013 Jan; 38(1):34-42. Merged cohort A and B data 

10. Bertelsen B, Oranje B, Melchior L, Fagerlund B, Werge TM, Mikkelsen JD, Tümer Z, Glenthøj BY. Association study of CHRNA7 promotor variants with sensory – and sensorimotor gating in schizophrenia patients and healthy controls – A Danish case-control study. Neuromolecular Med. 2015 Dec;17(4):423-30. Merged cohort A, B and C data



Cohort B

​1. Erritzoe D, Rasmussen H, Kristiansen KT, Frokjaer VG, Haugbol S, Pinborg L, Baaré W, Svarer C, Madsen J, Lublin H, Knudsen GM, Glenthoj BY. Cortical and Subcortical 5-HT2A Receptor Binding in NeurolepticNaive First Episode Schizophrenic Patients. Neuropsychopharmacol 2008; 33(10):2435-41. 

2. Rasmussen H, Erritzoe D, Andersen R, Ebdrup B, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg L, Baaré W, Svarer C, Lublin H, Knudsen GM, Glenthoj B. Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. Arch Gen Psychiatr 2010;67:9-16. 

3. Ebdrup BH, Glenthøj BY, Rasmussen H, Aggernaes B, Langkilde AR, Paulson OB, Lublin H, Skimminge A, Baaré W. Hippocampal and Caudate Reductions in Antipsychotic-Naïve First Episode. J Psychiatr Neurosci 2010;35:95-104. 

4. Aggernæs B, Glenthøj BY, Ebdrup BH, Rasmussen H, Lublin H, Oranje B. Sensorimotor Gating and Habituation in Antipsychotic-Naïve, First-Episode Schizophrenia Patients Before and After Six Months Treatment with Quetiapine. Int J Neuropsychopharmacol 2010;13(10):1383-95.

5. Rasmussen, H., Erritzoe, D., Ebdrup, B. H., Aggernaes, B., Oranje, B., Kalbitzer, J., Madsen, J., Pinborg, L. H., Baaré, W. F., Svarer, C., Lublin, H., Knudsen, G. M., Glenthoj, B.Y. Serotonin 2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine. Psychopharmacol (Berl) 2011;213(2-3):583-92. 

6. Ebdrup B, Skimminge A, Rasmussen H, Aggernæs B, Oranje B, Lublin H, Baaré W, Glenthøj B. Progressive striatal and hippocampal volume loss in initially antipsychotic-naïve first-episode schizophrenia patients treated with quetiapine: relation to dose and symptoms. Int J Neuropsychopharm 2011;14(1):69-82. 

7. Andersen R, Fagerlund B, Oranje B, Gade A, Rasmussen H, Ebdrup BH, Aggernaes B, Glenthoj BY. Cognitive Effects of Six Months Treatment with Quetiapine in Antipsychotic-Naïve First-Episode Schizophrenia. Psychiatr Res 2011;187(1-2):49-54. 

8. Nejad AB, Ebdrup BH, Siebner HR, Rasmusssen H, Aggernæs B, Glenthøj BY, Baaré WFC. Impaired temporopartietal deactivation with working memory load in antipsychotic naïve patients with firstepisode schizophrenia. World J Biol Psych 2011;12(4):271-81. 

9. Ebdrup BH, Rasmussen H, Arnt J, Glenthøj B. Serotonin 2A receptor antagonists for treatment of schizophrenia. Expert Opin. Investig Drugs 2011 Sep;20(9):1211-23. 

10. Oranje B, Aggernaes B, Rasmussen H, Ebdrup BH, Glenthøj BY. P50 Suppression and its Neural Generators in Antipsychotic-Naïve First-Episode Schizophrenia Before and After 6 Months of Quetiapine Treatment. Schizophr Bull 2013 March; 39(2):472-80. 

11. Hammer TB, Oranje B, Skimminge A, Ebdrup B, Aggernaes B, Glenthøj B, Baaré W. Structurel brain correlates of sensorimotor gating in antipsychotic naïve, first episode Schizophrenia patients. J Psychiatr Neurosci 2013 Jan; 38(1):34-42. Merged cohort A and B data

12. Andersen R, Fagerlund B, Rasmussen H, Ebdrup BH, Aggernaes B, Gade A, Oranje B, Glenthoj BY. The Influence of Impaired Processing Speed on Cognition in First-Episode Antipsychotic-Naïve Schizophrenic Patients. Eur Psychiatr 2013 Aug; 28(6):332-9. 

13. Nejad AB, Madsen KH, Ebdrup BH, Siebner HR, Rasmussen H, Aggernaes B, Glenthøj B, Baaré WFC. Neural markers of negative symptom outcomes in distributed working memory brain activity of antipsychotic-naīve schizophrenia patients. Int J Neuropsychopharmacol 2013 Jul;16(6):1195-204. 

14. Rasmussen H, Ebdrup B, Aggernaes B, Lublin H, Oranje B, Pinborg LH, Knudsen GM, Glenthøj BY. Norquetiapine and depressive symptoms in initially antipsychotic naïve first-episode schizophrenia. J Clin Psychopharmacol 2013 Apr;33(2):266-9. 

15. Rasmussen H, Ebdrup BH, Oranje B, Pinborg LH, Knudsen GM, Glenthøj B. Neocortical serotonin2A receptor binding predicts quetiapine associated weight gain in antipsychotic-naive first-episode schizophrenia patients. Int J Neuropsychopharmacol 2014;17(11):1729-36. 

16. Bertelsen B, Oranje B, Melchior L, Fagerlund B, Werge TM, Mikkelsen JD, Tümer Z, Glenthøj BY. Association study of CHRNA7 promotor variants with sensory – and sensorimotor gating in schizophrenia patients and healthy controls – A Danish case-control study. Neuromolecular Med. 2015 Dec;17(4):423-30. Merged cohort A, B and C data 

17. Nørbak-Emig H, Ebdrup BH, Fagerlund B, Svarer C, Rasmussen H, Friberg L, Allerup PN, Rostrup E, Pinborg LH, Glenthøj BY. Frontal D2/3 Receptor Availability in Schizophrenia Patients Before and After Their First Antipsychotic Treatment: Relation to Cognitive Functions and Psychopathology. Int J Neuropsychopharmacol. 2016 Apr 29;19;19(5). 

18. Nørbak-Emig H, Pinborg LH, Raghava JM, Svarer C, Baaré WF, Allerup P, Friberg L, Rostrup E, Glenthøj B, Ebdrup BH. Extrastriatal dopamine D2/3 receptors and cortical gray matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment. World J Biol Psychiatry. 2017 Oct;18(7):539-549. doi: 10.1080/15622975.2016.1237042. Epub 2016 Oct 26. 

19. Oranje B, Aggernaes B, Rasmussen H, Ebdrup BH, Glenthøj BY. Selective attention and Mismatch Negativity in Antipsychotic-Naïve, First-Episode Schizophrenia Patients Before and After Six months of Antipsychotic Monotherapy. Psychol Med 2017 Sep;12:2155-65. 

20. Kruiper C, Fagerlund B, Nielsen MØ, Düring S, Jensen MH, Ebdrup BH, Glenthøj BY, Oranje B. Associations between P3a and P3b amplitude and cognition in antipsychotic-naïve first-episode schizophrenia patients. Psychological Medicine 2018 Jun 7 [Epub ahead of print] Merged data B and C



Cohort C (PECANS STUDY)

​1. Nielsen MØ, Rostrup E, Wulff S, Bak N, Lublin H, Kapur S, Glenthøj B. Alterations of the Brain Reward System in Antipsychotic Naïve Schizophrenia Patients. Biol Psychiatr 2012 May 15; 71(10):898-905. 

2. Nielsen MØ, Rostrup, E, Wulff S, Bak N, Broberg BV, Lublin H, Kapur S, Glenthøj B. Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia. Arch Gen Psychiatr 2012 Dec; 69(12):1195-204. 

3. Düring S, Glenthøj BY, Andersen GS, Oranje B. Effects of dopamine D2/D3 blockade on human sensory and sensorymotor gating in initially antipsychotic-naïve, first-episode schizophrenia patients. Neuropsychopharmacol 2014;39:3000-8. 

4. Wulff S, Pinborg LH, Svarer C, Jensen LT, Nielsen M, Allerup P, Bak N, Rasmussen H, Frandsen E, Rostrup E, Glenthøj B. Striatal D2/3 Binding Potential Values in Drug-Naïve First-Episode Schizophrenia Patients Correlate with Treatment Outcome. Schizophr Bull 2015;41(5):1143-52. 

5. Bertelsen B, Oranje B, Melchior L, Fagerlund B, Werge TM, Mikkelsen JD, Tümer Z, Glenthøj BY. Association study of CHRNA7 promotor variants with sensory – and sensorimotor gating in schizophrenia patients and healthy controls – A Danish case-control study. Neuromolecular Med. 2015 Dec;17(4):423-30. Merged cohort A, B and C data 

6. Düring S, Glenthøj BY, Oranje B. Effects of Blocking D2 Receptors on Mismatch Negativity and P3a Amplitude of Initially Antipsychotic Naïve, First Episode Schizophrenia Patients. Int J Neuropsychopharmacol. 2015 Oct 9. pii: pyv109. doi: 10.1093/ijnp/pyv109. PMID: 26453696. 

7. Ebdrup BH, Raghava JM, Nielsen MØ, Rostrup E, Glenthøj B. Frontal fasciculi and psychotic symptoms in antipsychotic-naïve schizophrenia before and after selective Dopamine D2/3 receptor blockade. J Psychiatry Neurosci. 2016 Mar;41(2):133-41. 

8. Nielsen MØ, Rostrup E, Wulff S, Glenthøj B, Ebdrup BH. Striatal reward activity and antipsychotic associated weight change in initially antipsychotic-naïve schizophrenia patients. JAMA Psychiatry. 2016 Feb 1;73(2):121-8. 

9. Nordholm D, Poulsen HE, Hjorthøj C, Randers L, Nielsen MØ, Wulff S, Krakauer K, Nørbak-Emig H, Henriksen T, Glenthøj B, Nordentoft M. Systematic oxidative DNS and RNA damage are not increased during early phases of psychosis: A case control study. Psychiatry Res. 2016 Jul 30;241:201-6. 

10. Bak N, Ebdrup BH, Oranje B, Fagerlund B, Jensen MH, Düring SW, Nielsen MØ, Glenthøj BY, Hansen LK. Two subgroups of antipsychotic-naïve, first-episode schizophrenia patients identified with a Gaussian Mixture Model on cognition and electrophysiology. Transl Psychiatry. 2017 Apr 11;7(4):e1087. doi: 10.1038/tp.2017.59. 

11. Nielsen MØ, Rostrup E, Broberg BV, Wulff S, Glenthøj BY. Negative symptoms and reward disturbances in schizophrenia before and after antipsychotic monotherapy. Clin EEG & Neurosci 2018 Jan;4(1):36-45. (IF 2.163)

12. Anhøj S, Nielsen MØ, Jensen MB, Ford K, Fagerlund B, Williamson P, Glenthøj B, Rostrup E. Alterations of Intrinsic Connectivity Networks in Antipsychotic-Naïve First-Episode Schizophrenia. Schizophr Bull 2018. Epub ahead of print doi:10.1093/schbul/sbx171 

13. Nordholm D, Rostrup E, Randers L, Mondelli V, Nielsen MØ, Randers L, Nielsen MØ, Wulff S, Nørbak-Emig H, Broberg BV, Krakauer K, Dazzan P, Zunszain PA, Nordentoft M, Glenthøj B. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients 2018 online publ March 26 DOI: https://doi.org/10.1016/j.psyneuen.2018.03.015 

14. Jessen K, Rostrup E, Mandl RCW, Nielsen MØ, Bak N, Fagerlund B, Glenthøj B, Ebdrup BH. Cortical structures and their clinical correlates in antipsychotic-naïve schizophrenia patients before and after six weeks of dopamine D2/3 receptor antagonist treatment. Psychol Med. 2018 May 8:1-10. doi: 10.1017/S0033291718001198. [Epub ahead of print] 

15. Kruiper C, Fagerlund B, Nielsen MØ, Düring S, Jensen MH, Ebdrup BH, Glenthøj BY, Oranje B. Associations between P3a and P3b amplitude and cognition in antipsychotic-naïve first-episode schizophrenia patients. Psychological Medicine 2018 Jun 7 [Epub ahead of print] Merged data B and C




 

 

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