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Projects

Research projects conducted at CNDR aim to improve treatment of affective disorders. Below are descriptions of current and upcoming projects.  


"Healthy Brain" – training of cognitive disorders after depression

This PhD project is in collaboration with the company Brain+, who have developed an application for smartphones and tablets that enables training of the cognitive deficits, that many formerly depressed patients suffer from. This is done in an intelligent, user-friendly and efficient way. The projects objective is a scientific evaluation of the application’s potential.

Right now the project is on standby.
 
Researcher: 
Supervisor: Professor, MD Poul Videbech

​The Danish Neuropsychological Study of Adverse Effect of ECT (DANSECT)

The purpose is to describe the frequency, severity and duration of the cognitive side effects after ECT, as well as find predictors of their occurrence. There will be a special focus on autobiographical memory disorders. The perspective is that you will be able to advise the individual patient better. advantages and disadvantages of the treatment. The project is primarily funded through the Government's SATS-funds.
 
Researcher: PhD student, Neuropsychologist André Mathiassen​
Supervisor: Professor, MD Poul Videbech

​​ECT and depression - understanding treatment response and blood-brain-barrier changes

As ECT is used worldwide, the development of precise methods for predicting which patients will benefit from treatment will be of paramount importance to both physicians and patients. In the current study, we have two important goals: 1) To develop easily accessible and valid methods based on MRI scans that can predict which patients will achieve the effect of ECT. 2) To conduct a potentially groundbreaking proof-of-concept study of the blood-brain barrier (BBB) ​​before and after ECT.

Researcher: PhD student, MD Christoffer Lundsgaard
Supervisor: Professor, MD Poul Videbech

DEPRES-ST: ​​A randomized controlled trial of schema therapy for patients with intractable depression in psychiatry

The PhD project aims to investigate a special form of psychotherapy (schedule therapy) in a randomized controlled trial with chronically depressed patients. The project is funded by Trygfonden.​

​Researcher: Psychologist Ida-Marie Arendt
Supervisor: ​​Professor, MD Poul Videbech​
Project leader: Psychologist, senior researcher, PhD, Stine Bjerrum Møller​

Killing of infants - ​a forensi​c psychiatri​c examination 1992-2016 ​​​​​​​​​​​

The project is made in collaboration with the Institute of Forensic Medicine, Skejby hospital. Initially, we will review the mental statements as well as the judicial council's statements for the perpetrators who have killed their child during the first year of its life. The purpose is to describe mental illness and other factors that contribute to the murder being committed in order to prevent new killings. It is the plan to make a follow-up in Danish registers in order to description the treatment, prognosis and later renewed crime.
 
Researcher: MD Charlotte Fergo
Supervisor: Professor, MD Poul Videbech

Mechanisms behind the antidepressant effect of ECT - a multimodal MRI study

Electroconvulsive therapy (ECT) is the most effective method of treating severe depression. It has been used in clinical practice for over 80 years, but the mechanisms behind the antidepressant effect and the cognitive side effects remain unclear. The main purpose of the project is to illuminate these mechanisms.

Researcher: Post doc, PhD, MD Krzysztof Gbyl
Supervisor: Professor, MD Poul Videbech

Project with driving simulator

The driving simulator will be used in the DANSECT project to test how the cognitive function of research patients is. In addition, the plan is that it also will be used to test how much mental illness and psychopharmacological treatment affect cognitive function.

Research assistent: Research assistant, stud.med. Michelle Heesche​
Supervisor: Professor, MD Poul Videbech

​​ZA-RAA - Validation and testing of screening instruments for Autism Spectrum Disorder​​

Autism Spectrum Disorder in adults has only received the necessary attention and space in psychiatry in recent decades. The diagnostic and especially differential diagnostic knowledge among healthcare providers is limited. Good screening tools can support clinicians and contribute to faster and more effective diagnosis. In the first research project from Team ADHD & Autism, we have chosen to focus on testing screening instruments. The project is two-part and will examine 2 screening questionnaires with relevance for autism investigation. The main aim is to test a newly developed questionnaire: the schiZotypal Autism Questionnaire (ZAQ). In addition, we will test a Danish translation of a well-known and widespread questionnaire: Ritvo Autism Asperger Diagnostic Scale – Revised (Danish version) (RAADS-R-DK).

Researcher: MD Rizwan Parvaiz​
Supervisor: professor, MD Poul Videbech​

​​ANIMAL C​​ON​​TA​CT​​​​​

CNDR will collaborate with Foulum in a 4-year project concerning use of therapy animals. The project consists of two parts, with CNDR participating in the second part, consisting of two case studies - one with nursing home residents and one with war veterans. CNDR participates in the case study on war veterans, where they will examine the effect of a service dog's presence on war veterans with PTSD - both in challenging and non-challenging situations - ie. with high and low stress loads. The project is funded by the Trygfonden.

Researcher: Professor, cand.psyk. Lene Vase
Supervisor: Professor, MD Poul Videbech

​​Precision Brain-Circuit Therapy (Precision-BCT)

CNDR is a partner in a research project at Hvidorvre Hospital, where the goal is to develop and commercialize a personalized brain stimulation (Precision-BCT) to restore brain functions in treatment-resistant depression. The project is funded by the Innovation Fund.

Researcher:
Supervisor: Professor, MD Poul Videbech

​Metabolic and transcriptomic profiling of women with postpartum depression

Postpartum depression (PD) is a serious disorder that affects 5-15% of all women after childbirth. Untreated, the disease can have serious consequences for mother and child in both the short and long term. Very little is known about the specific causes of PD in women without a previous mental illness. However, there is some evidence that reproductive hormones, possibly interacting with certain genes, play an important role in the development of the disease in these women. We will utilize entirely new technology to investigate metabolic activity and what genes are expressed in PD women compared to healthy women shortly after birth. At the same time, we are taking advantage of the national birth cohort study, in which 100,000 women participated and where blood samples taken during their pregnancy are now stored. Based on the results of the first study, we will examine markers specific to PD for their ability to predict a future PD in the latter cohort.
 
Researcher: Cand.scient.san.publ. Marie-Louise Hee Rasmussen
Supervisor: Professor, MD Poul Videbech

Neurobiological effects of work-related adjustment disorder

The purpose of this project is to identify neurobiological changes in the dopaminergic binding potential of the human brain's reward system and their possible correlation with the psychological symptom anhedonia, defined as a common symptom of depression, anxiety and stress. The study population is patients from the Department of Occupational Health, Odense University Hospital.
 
Researcher: M.Sc., engineer Saga Steinmann
Supervisor: Professor, MD Poul Videbech

Sleep quality and effects of ball blankets on insomnia due to depression in ambulant psychiatry

The purpose of this PhD project (PhD in Business) is to study if a Protac Ball BlanketTM is helpful as an innovative non-pharmacological alternative to the medical treatment of insomnia among out-patients with depression psychiatry.
 
Researcher: Cand.cur., nurse Sanne Toft Kristiansen
Supervisor: Professor, MD Poul Videbech

​Inflammation and Neuroprogression in Anorexia Nervosa

In this PhD project we want to study increased inflammation and clinical signs of neuroprogression such as impaired social cognition and loss of emotional regulation capacity in patients with anorexia. Inflammation is also associated with neurodegeneration in schizophrenia and Mood Disorders.
 
Researcher: MD Klara Rasmussen
Supervisor: Professor, MD Poul Videbech

Cancer Patients with Severe Mental Disorder (CASEMED)

​The PhD project is carried out in collaboration with the Department of Cancer, Aarhus University Hospital and is financed by The​ Danish Cancer Society. The background is that cancer patients with severe mental illness (SMD) constitute a very vulnerable group with poor symptom control and complex psychosocial problems. Their life expectancy is greatly shortened. There are three purposes with the project: To investigate the specialized palliative care offered to cancer patients with SMD in their recent time (EOL). To explore experiences, views and barriers regarding EOL among cancer patients with SMD from the point of view of the palliative care staff. To develop and test a complex intervention (The Danish cancer-SMD EOL care model) among cancer patients with an already existing SMD. This will be done with a combination of questionnaire surveys, qualitative studies and register studies.​​

Researcher: Magister Josefine Maria Bruun and professor, MD Mette Asbjørn Neergaard
​Supervisor: Professor, MD Poul Videbech



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