Preclinical studies of DNA damage and repair in depression

​Anders Jørgensen Psykiatrisk Center København har modtaget et forberedelsesstipendium til forberedelse af en post.doc.

DNA damage from oxidation is a putative molecular link between major depression and its associated signs of accelerated aging, i.e. cognitive dysfunction, dementia risk and metabolic dysregulation. In this study, we will investigate the role of Base Excision Repair, theprinicipal pathway by which neurons repair oxidative DNA damage, in a rodent model of depression (chronic restraint stress). Specifically, we will use mice genetically deficient in NEIL1, an enzyme acting in the first steps of BER, and investigate whether these animals are more sensitive to the neuro-behavioural and metabolic consequences of chronic stress. The study will be performed in cooperation between the Laboratory of Molecular Gerontology, National Institute of Health, USA, and the Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, Denmark. The study will potentially open new biological pathways by which to treat the severe cognitive and metabolic disturbances associated with depression and other mental disorders.

The study will be performed in cooperation between the Laboratory of Molecular Gerontology, National Institute of Health, USA, and the Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, Denmark.​
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