Biology of bipolar disorder

Using a longitudinal repeated measures design of patients with bipolar disorder and healthy control subjects, our results support a potential role for biomarkers of:

  1. oxidatively generated damage to nucleosides (urinary 8-oxodG and 8-oxoGuo)
  2. inflammation (IL-6 and IL-18)
  3. neurotrophins (BDNF)
  4. Glycogen synthase kinase-3b (GSK-3b)
  5. expression of genes related to the arachidonic acid cascade (PTGD) and mitochondrial function and DNA repair mechanisms
  6. a composite gene expression measure biomarker.

A study on cerebrospinal fluid based biomarkers for bipolar disorder is ongoing. The BIO study is ongoing (see Ongoing projects)