High risk studies in affective disorders

​​The RISK group: Risky: Interconnect  Signatures of Knowing in advance.

  1. Previous findings from both a cross sectional and a follow-up study of twins at high and low familial risk for affective disorders respectively showed that
  2. familial risk,
  3. subclinical anxiety and depressive symptoms and higher neuroticism scores
  4. impaired stress tolerance
  5. discrete cognitive dysfunction

are predictive of later illness onset

The two biological peripheral markers:

  1. cortisol levels
  2. Brain Derived Neurothropic factor (BDNF) levels

were not found to be predictive of later illness onset.

Thus, having a first-degree relative with affective disorder matters and illustrates that high-risk studies are extremely informative.  The future aim is therefore an extension this research aiming to map individual risk profiles to improve early treatment and prevention.


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