Chronotherapeutics

​We aim to develop new treatment methods based on chronobiological principles using sleep manupulations, sleep stabilization, bright light therapy and dynamic lighting.

Upcoming projects

  • Seasonality in mental healthcare referrals – Seasonment 

  • Daylight, what makes the difference? 

Finalized projects

  • SAFE-II: Can electronic self-monitoring with closed loop feedback focusing on regulation of the sleep-wake cycle reduce relapse of depression after discharge from a psychiatric ward (2016-2020)

A Randomized Controlled Clinical Trial (RCT) included patients before discharge from a psychiatric inpatient ward and in the early faces of their stay at the Intensive Affective Outpatient Clinic (IAOC) and followed them for four weeks. Patients were randomized to one group using electronic self-monitoring with feedback from health investigators, and another group that in addition to the electronic self-monitoring was guided to attain signals to the circadian clock to stabilize the, sleep-wake cycle (diet, daylight exposure, sleep, and behavioral motivation towards social function and physical activity). In all, 103 patients were included in the trial. From the qualitative data in this study, we found that patients expressed a feeling of support and safety by participating in the study. They especially felt that the electronic self-monitoring with continuous feedback from investigators provided them with an important reflection on their activity and mental health. The depression severity decreased significantly in both groups, comparable to what was found in the SAFE-I study. Readmission rates were low in both groups (7.8 %).
Analysis of results are in preparation
  • SAFE-I: Electronic self-monitoring with clinical feedback in depression, a feasibility study (2015-2016)

We used a self-monitoring system to investigate the connection between sleep and depression after discharge from a psychiatric inpatient ward to the Intensive Affective Outpatient Clinic (IAOC) in combination with weekly feedback from investigators by telephone. Patients evaluated the electronic system with a high usability score, and there was a high data entry rate. Patients gradually delayed their sleep after discharge from the psychiatric inpatient ward, and this delay of sleep was found to be related to a worsening of depression.
Please see publication in the Publication section


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