Self-regulation in children with ADHD and Tourette Syndrome-RAR (Regulation and Reward) project

​Principle investigator professor Kerstin J. Plessen.

Behavioral monitoring, emotional regulation and reward systems for children with Tourette syndrome compared to children with ADHD – neuropsychology and imaging.

The role of emotional factors in children with Tourette syndrome is still relatively unknown, and studies on motivation and reward systems have mainly involved adults with Tourette’s. We therefore research the ability of emotional regulation in children with Tourette syndrome, children with ADHD, a comorbid group with ADHD and Tourette syndrome and finally a group of healthy subjects (30 subjects in all four groups).

In the second part of the study, the same subjects were examined in a functional MRI study (in collaboration with Prof. Hartwig Siebner at the Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen) during a task that simulated a reward system to recognize the neurophysiological correlations of behavior in this group. The results of this study could play an important role in planning a functional MRI study that can measure neurobiological correlations for the effect of treatment, regarding habit reversal training.

Finally, in cowork with Prof. Birte Glenthøj, CINS, Prof. Ulrich Gether, KU, and Prof. Habekost, we are examining the influence of medication (Methylphenidate) on the neuropsychological functions of children with ADHD, in comparison to a controlgroup (not receiving medication) in the context of “Attention to Dopamine”.

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